The Low-Frequency Ultrasound Influence on Lidocain and Glycosaminoglycans

The investigation of the ultrasound effect on medicinal substances is an important problem since currently it has a sufficiently wide application in medical practice. The article presents the results of experimental investigations of the low-frequency ultrasound effect on lidocaine and glycosaminoglycans (hyaluronic acid and sodium hyaluronate). Based on the results of IR spectrum analysis of the above-mentioned substances solutions, we found that there were no changes in their structure. From the findings of the research we draw the conclusion that in lidocaine as well as in hyaluronic acid and sodium hyaluronate under exposure to the low-frequency ultrasound the chemical bonds are not broken down and the substance composition does not change. The results obtained make it possible to use the low-frequency ultrasound jointly with lidocaine, hyaluronic acid and sodium hyaluronate in order to create new medical technologies, for example, in aesthetic medicine and cosmetology.

References

[1] Molchanov G.I. Ul’trazvuk v farmatsii [Ultrasound in pharmacy]. Moscow, Meditsina Publ., 1980. 176 p.

[2] Ulashchik V.S., Chirkin А.А. Ul’trazvukovaya terapiya [Ultrasound therapy]. Minsk, Belarus’ Publ., 1983. 254 p.

[3] Elpiner I.E. Biofizika ul’trazvuka [Biophysics of ultrasound]. Moscow, Nauka Publ., 1978. 286 p.

[4] Akopyan V.B., Ershov Yu.A. Osnovy vzaimodeystviya ul’trazvuka s biologicheskimi ob’ektami [Basics of ultrasound interaction with biological objects]. Moscow, MGTU im. N.E. Baumana Publ., 2005. 224 p.

[5] Gorshkova V.M. Impact of low-frequency ultrasound on biological tissue. Vestn. Mosk. Gos. Tekh. Univ. im. N.E. Baumana, Estestv. Nauki [Herald of the Bauman Moscow State Tech. Univ., Nat. Sci.], 2015, no. 6, pp. 62-72 (in Russ.). DOI: 10.18698/1812-3368-2015-6-62-72

[6] Loshchilov V.I., Parvan I.G. Experimental-theoretical investigation of low-frequency ultrasound application in medicine. Vestn. Mosk. Gos. Tekh. Univ. im. N.E. Baumana, Priborostr. [Herald of the Bauman Moscow State Tech. Univ., Instrum. Eng.], 1993, no. 4, pp. 74-78 (in Russ.).

[7] Merleev А.А., Gorshkova V.M., Nesterov A.V. Study of feasibility to control effectiveness of preparation trental, inserted using phonophoresis method. Vestn. Mosk. Gos. Tekh. Univ. im. N.E. Baumana, Priborostr. [Herald of the Bauman Moscow State Tech. Univ., Instrum. Eng.], 2001, no. 3, pp. 113-119 (in Russ.).

[8] Gorshkova V.М., Rozhdestvin V.N. Skin treatment by means of ultrasound. Biomeditsinskaya radioelektronika [Biomedical Radioelectronics], 2007, no. 10, pp. 62-65 (in Russ.).

[9] Gorshkova V.M., Savchenko S.V. The new technology of local anaesthetic by means ultrasonic of low frequent. Biomeditsinskaya radioelektronika [Biomedical Radioelectronics], 2012, no. 11, pp. 23-26 (in Russ.).

[10] Sharova А.А., Gubanova E.I., Parsagashvili E.Z. et al. Novaya kosmetologiya. In"ektsionnуе metody v kosmetologii [New cosmetology. Injection methods in cosmetology]. Moscow, ID Kosmetologiya i meditsina Publ., 2014. 480 p.

[11] Gorshkova V.М., Savchenko S.V. New method to increase the pain barrier by ultrasonic. Tekhnologiya zhivykh sistem [Technologies of Living Systems], 2011, no. 1, pp. 56-58 (in Russ.).

[12] Gorshkova V.М., Savchenko S.V. Investigation of possibilities to use ultrasound for a subcutaneous injection of anaesthetic. Meditsinskaya tekhnika [Medical Engineering], 2013, no. 1, pp. 30-32 (in Russ.).

[13] Kvashnin S.E., Bosova E.V. Investigation of spectral characteristics of medical ultrasound piezoelectric transducers and rod concentrators of longitudinal oscillations. Vestn. Mosk. Gos. Tekh. Univ. im. N.E. Baumana, Priborostr. [Herald of the Bauman Moscow State Tech. Univ., Instrum. Eng.], 1993, no. 4, pp. 86-93 (in Russ.).

[14] Kvashnin S.E. Designing of compound electroacoustic systems for medical purposes. Biomeditsinskaya radioelektronika [Biomedical Radioelectronics], 1999, no. 3, pp. 61-70 (in Russ.).

[15] Kvashnin S.E. Optimization of configuration of ultrasound rod instruments-concentrators of longitudinal oscillations for surgery. Biomeditsinskaya radioelektronika [Biomedical Radioelectronics], 2001, no. 2, pp. 55-61 (in Russ.).

[16] Kvashnin S.E. Mathematical modeling of errors in implementation of lateral dimensions of medical waveguide instruments. Biomeditsinskaya radioelektronika [Biomedical Radioelectronics], 2001, no. 9, pp. 43-48 (in Russ.).

[17] Kvashnin S.E., Lobachev А.А. Low-frequency ultrasound apparatus for surgery. Biomeditsinskie tekhnologii i radioelektronika [Biomedical Technologies and Radioelectronics], 2006, no. 10, pp. 43-49 (in Russ.).

[18] Kvashnin S.E., Maksimov А.А. Passage through resonance of ultrasonic langevin electroacoustic transducers for surgery. Biomeditsinskaya radioelektronika [Biomedical Radioelectronics], 2012, no. 10, pp. 38-44 (in Russ.).

[19] Kvashnin S.E., Мaksimov А.А. Investigation of heating effect of deformation antinode area on amplitude-frequency characteristics of ultrasound oscillating system. Meditsinskaya tekhnika [Medical Engineering], 2013, no. 1, pp. 38-41 (in Russ.).

[20] Gorshkova V.M., Savchenko S.V. Potential use of ultrasound for subcutaneous delivery of anaesthetics. Biomedical Engineering, 2013, vol. 47, no. 1, pp. 36-38.