Study of the Properties of Nanoscale Calcium Carbonate Stabilized with Hyaluronic Acid

Abstract

The aim of this study is to present a novel synthesis technique and investigate the properties of nanoscale calcium carbonate samples stabilized with hyaluronic acid, a biopolymer. The samples were produced through chemical precipitation in an aqueous environment, utilizing calcium acetate as a calcium-containing precursor, hyaluronic acid as a stabilizing agent, and ammonium carbonate as a precipitating agent. A sample of nanosized calcium carbonate, modified with the biopolymer, was analyzed using dynamic light scattering, acoustic, and electroacoustic spectroscopies, scanning electron microscopy, X-ray diffraction, and computational quantum chemical modeling techniques. The results obtained from photon correlation spectroscopy analysis indicated that the sample had a hydrodynamic radius less than 30 nanometers and an electrophoretic mobility close to zero. Investigation of the phase composition revealed that the sample consisted of a single phase with a rhombohedral crystalline structure. Based on the analysis of the microstructural features of nanoscale calcium carbonate stabilized with hyaluronic acid, it was found that the sample consists of cubic particles with dimensions ranging from 0.3 to 5 microns. These particles are composed of smaller nanoparticles. Quantum chemical modeling was used to determine the optimal molecular structure of the complex formed between calcium carbonate nanoparticles and hyaluronic acid. The modeling also allowed us to calculate the quantum characteristics of this complex

The work was carried out with the state financial support of the Ministry of Science and Higher Education of the Russian Federation (project FSRN-2023-0037)

Please cite this article in English as:

Blinov A.V., Rekhman Z.A., Askerova A.S., et al. Study of the properties of nanoscale calcium carbonate stabilized with hyaluronic acid. Herald of the Bauman Moscow State Technical University, Series Natural Sciences, 2024, no. 6 (117), pp. 72--87 (in Russ.). EDN: BXLDEW

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