Synthesis of Nanosized Zinc Phosphate Stabilized with Biologically Active Substances

Abstract

The article presents the results of a study of the interaction of zinc phosphate with biologically active substances using the method of quantum chemical modeling, which obtained models of molecules of biologically active substances (essential amino acids), as well as molecular systems Zn₃(PO₄)₂--an essential amino acid, in which the interaction of zinc phosphate with an amino acid occurred through an oxygen atom attached to the phosphorus atom in zinc phosphate, and the ionized amino group of the amino acid. As a result of quantum chemical modeling, it is established that the molecular system Zn₃(PO₄)₂, an essential amino acid, is energetically advantageous and chemically stable. The optimal configuration with the largest total energy difference (73.646 kcal/mol) and chemical rigidity (0.144 eV) is the Zn₃(PO₄)₂--lysine molecular system, in which the interaction occurs through the ionized ε-amino group of lysine. The results of the analysis of the microstructure of zinc phosphate nano-particles stabilized with L-lysine show that the surface of the samples consists of large aggregates with diameters of 6--17 µn, which are small spherical particles with dimensions of 100--150 nm. The results of the analysis of the elemental composition allowed us to establish the presence of elements such as zinc and phosphorus in the structure. The phase composition of the samples is studied, as a result, it is determined that the sample of zinc phosphate nanoparticles stabilized with L-lysine has orthorhombic syngony with the space group P nma. The samples were examined by IR spectroscopy, which revealed that the amino acid interaction occurs when phosphate binds through amino groups in the amino acid molecule

The work was carried out with the financial support of the Council for Grants of the President of the Russian Federation (project SP-476.2022.4), using the equipment of the North Caucasian Federal University Collective Use Center with the financial support of the Ministry of Science and Higher Education of the Russian Federation (unique project identifier RF-2296.61321H0029), and as part of the program to support the development of research teams of Stavropol State Agrarian University, implemented with the financial support of the Program of Scientific "Priority 2030" Academic Leader-ship Program

Please cite this article in English as:

Blinova A.A., Rekhman Z.A., Kastarnova E.S., et al. Synthesis of nanosized zinc phosphate stabilized with biologically active substances. Herald of the Bauman Moscow State Technical University, Series Natural Sciences, 2025, no. 1 (118), pp. 119--136 (in Russ.). EDN: FURTAC

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