Acetone, Ethanol and Isopropanol as a Set of Biomarkers in the Exhaled Breath of Patients with Type 1 Diabetes

Authors: Nebritova O.A., Demkin P.P., Morozov A.N., Berezhanskiy P.V., Anfimov D.R., Fufurin I.L. Published: 14.12.2023
Published in issue: #6(111)/2023  
DOI: 10.18698/1812-3368-2023-6-39-54

Category: Physics | Chapter: Instrumentation and Methods of Experimental Physics  
Keywords: quantum cascade laser, infrared spectroscopy, type 1 diabetes, chronic disease, biomarker, exhaled air, quality of life


Type 1 diabetes mellitus (autoimmune diabetes) is a chronic disease characterized by the insulin deficiency due to the loss of the pancreatic beta cells. According to the International Diabetes Federation, 537 million people (~ 8 %) suffer from this disease. According to statistics, by 2030 the number of patients suffering from diabetes would increase to 643 million, and by 2045 it would amount to 783 million people in the world. Non-invasive diagnostics makes it possible to identify the disease at an early stage, which will make it possible to reduce the burden on the country's healthcare system and improve the quality of life of the population. The paper describes an experimental setup based on the infrared laser spectroscopy. The main setup elements include a quantum cascade laser emitting in the range of 5.3--12.8 μm with peak power of 150 mW and a tuning step of 1 cm--1, as well as a multi-pass Herriot gas cell with the optical path length of 76 m. The obtained spectra of exhaled breath air were analyzed with healthy volunteers (60 people) and patients suffering from the type 1 diabetes (60 people). Concentration range diagrams of three main biomarker molecules (acetone, ethanol and isopropanol) were calculated. Median values of the obtained diagrams of the biomarker molecules concentration range make it possible to reliably differentiate volunteers from the different health groups. The results could be used to determine reference values for the biomarker molecules concentration in the exhaled air and to design and develop devices for rapid diagnostics of diseases using spectral analysis of the exhaled air

The work was carried out within the framework of implementing the Strategic Academic Leadership Program "Priority-2030", approved by the Resolution of the Government of the Russian Federation dated May 13, 2021 no. 729

Please cite this article in English as:

Nebritova O.A., Demkin P.P., Morozov A.N., et al. Acetone, ethanol and isopropanol as a set of biomarkers in the exhaled breath of patients with type 1 diabetes. Herald of the Bauman Moscow State Technical University, Series Natural Sciences, 2023, no. 6 (111), pp. 39--54 (in Russ.). DOI: https://doi.org/10.18698/1812-3368-2023-6-39-54


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